Endothelial Insult
Cardiovascular disease is a leading cause of death in the western world despite our vast knowledge on the subject. The pump gets the bulk of the attention when you think of your cardiovascular system, but the hoses are where the degradation begins. Inside all our blood vessels is a thin single cell layer known as the endothelium. Think of it as a smooth protective film that helps keep the lumen open and flowing properly. Imagine over time this film becomes damaged and must repair itself, like how a superficial wound will scab over. The technical term for this scab is atherosclerotic plaque and it clogs up our blood vessels in the same manner that a hair can clog a drainpipe. As our endothelium ages it simply becomes less efficient and inflammatory particles accumulate over time. In extreme dysfunction scabs upon scabs accumulate on top of one another creating what is called a fibrous cap. The larger this becomes the more it sticks out from the vessel wall exposing it to the sheer forces of your blood pumping, worst case scenario it can snap off and be whisked away by the blood stream resulting in a heart attack or stroke depending upon the end location.
There is an interesting test that can be done to help determine endothelial dysfunction, using an ultrasound of the brachial artery and a blood pressure cuff. Pumping the cuff up and releasing it causes a rush of blood that can be measured with the ultrasound. A recent study using this method showed that covid survivors almost a year post infection displayed increased endothelial dysfunction compared to matched controls. Labs in these same patients would also show an elevated high sensitivity CRP and tumor necrosis factor that far out as well. They were even able to pull and compare labs to when the patients were hospitalized (table 2). These further confirm the inflammatory aftermath of infection and all the negative consequences that may follow. The study also raises a particularly important question: how long do these effects last?
The past two years have of course been the single largest endothelial insult in human history with the widespread transmission of Covid-19. The cardiovascular complications of infection are well documented and in no small part due to the inflammatory state that infection can induce. Some parties have used this as an argument for more extensive covid-19 vaccination of the population, downplaying potential adverse events from the vaccine in exchange for the potential benefits. If the vaccines were truly preventing transmission, then their adverse events may be worth the cost, but if you are on booster number five and you still get covid, we must now ask what role did five rounds of immunization play in your current inflammatory status? Is the inflammation caused by the vaccine additive or synergistic with repeat doses? The recent guidance from the CDC to increase the time in between shots to prevent adverse events seem to suggest this idea has merit.
A few months ago, some brave soul had the stones to publish some comments looking at cardiovascular biomarkers post vaccination in his patients at a preventative cardiology practice. The original version can be found below; it is a short read.
Honestly not sure how it was allowed to be published due to the author’s conclusion that sets off every alarm at thought police headquarters.
““mRNA [vaccines] dramatically increase inflammation on the endothelium and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis, cardiomyopathy, and other vascular events following vaccination.”
I waited several months to see if the author would continue to exist, which is the case because several corrections were made in December (link below).
https://www.ahajournals.org/doi/10.1161/CIR.0000000000001053
There were indeed multiple corrections including grammar, spelling, and rewording that appears to obfuscate the conclusion but no corrections to the underlying data. The idea that the vaccines would cause an increase in inflammatory biomarkers is not far-fetched; it is exactly how they are supposed to work. The hope is that these elevated levels are transient and issues due to it are mild and worth the benefit. The labs were drawn between 2 weeks and 2.5 months after vaccination and compared to the patient’s own baseline scores.
Jacob Hyatt Pharm D.
Father of three, Husband, Pharmacist, Realtor, Landlord, Independent Health and Medicine Reporter
https://substack.com/discover/pharmacoconuts
Bitcoin GtjoZgxE7WpTkWRE6JiEiXfUpqbWKxH4g
Litecoin ML1N31UVz6sRfo2m2oLaorXgPexUtv3Q3t
Thank you for Reading feel free to share!
Further reading and references
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8882598/
https://www.ahajournals.org/doi/10.1161/CIR.0000000000001053
https://pubmed.ncbi.nlm.nih.gov/35064792/
https://pubmed.ncbi.nlm.nih.gov/35013457/
